The level of harm from the long-term use of Amyl Nitrite is generally low, however some of the long-term effects can range from mild allergic reactions to potentially life threatening methaeglobinaemia – a blood disorder that can lead to inadequate oxygen supply to body tissue. Frequent use can also cause a rash to form around the mouth, nose and eyes, or any skin that regularly comes into contact with the vapour. This can look like a skin irritation. Direct fluid contact with skin can cause burns and should be avoided.

People who are anaemic, pregnant, have high blood pressure, or have increased pressure within the skull (head injury or brain haemorrhage) should avoid using amyl nitrite as this can increase the risk of harmful effects.